how does our white blood cells works
FUNCTIONS OF WHITE BLOOD CELLS
Today I am going to share some knowledge that I learned which is " How Our White Blood Cells Work inside Our Body".
To start off, I would like to tell everyone that the number of red blood cells(RBC) in our body outnumbered the number of white blood cells(WBC), at about 5000-10,000 cells per microliter of blood. That means the ratio between our RBCs and WBCs is 700:1. You guys must be thinking that why our WBCs is so little. Eventhough their number is less than RBCs but they are powerful and strong like the SUPERMANN💪💪💪
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| Cells in red is called the Red Blood Cells while the cells in white is called the White Blood Cells |
The number of WBCs in our body can increase above 10,000µ/L when there are invading microbes ( protection response), strenuous exercise, anesthesia and surgery. This phenomenon is what we called as Leckocytosis. An abnormally low WBCs which is below 5000µ/L is termed as Leukopenia. This condition is never beneficial for us as it may cause by radiation and certain chemotherapeutic agents. So, everyone have you guys experience any of this situations??? If you have make sure to you meet your doctor and those who not make sure to keep your body healthy. We want everyone to live happily and healthy because WE ARE TOO YOUNG TO DIE NOW
https://www.youtube.com/watch?v=7VQU28itVVw
Neutrophils and macrophages are active in phgocytosis where they digest bacteria and dispose of dead cells. Several different chemicals are released by microbes and inflamed tissues attract phagocytosis, a phenomenon called chemotaxis. The substances that provide stimuli for chemotaxis include toxins produced by microbes, kinins, which are specialized products of damaged tissues and some colony-stimulating factors (CFS). The CSF also enhance the phagocytic activity of neutrophils and macrophages.
When we sick due to infection, the first WBCs that respond is the neutrophils. They respond most quickly to tissues destruction by bacteria. After engulfing the pathogen, a neutrophils unleashes several chemicals to destroy the pathogen. These chemicals include enzyme lysozyme that responsible destroy the pathogens, some strong oxidants such as the superoxide anion (O2-), hydrogen peroxide (H2O2) and hypochlorite anion (OCI-).
Did you know that hypochlorite anion is similar to your household bleach?
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| Just like how you want to remove the stains on your clothes that how the neutrophils remove the pathogens |
Inside the neutrophils also we have the defensins, proteins that exhibit a broad range of antibiotic activity against the bacteria and fungi. Within the neutrophils, vesicles containing defensins merge with phagosomes containing microbes. Defensins form peptide "spear" that poke holes in microbe membranes, resulting the loss cellular contents kills the invader.
Now we finish talk about neutrophils. Let move on with eosinophils. As everyone knows that responsible in allergic reactions, parasitic infections and autoimmune diseases. When they leave the capillaries and enter the tissue fluid, eosinophils will released enzymes called histaminase that fight off with the effects of histamine and other substances involved in inflammation during allergic reactions. Eosinophils also phagocytize antigen-antibody complexes and effective against certain parasitic worms. When the number of eosinophils high in our blood, don't be surprised. This show that our body are having allergic reactions or parasitic infection.
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| Eosinophils vs Parasite |
Basophils as you know they are the rarest white blood cells in our body. At sites of inflammation, basophils leaves the capillaries, enter the tissues and release granules that contain heparin, histamine, and serotonin. These substances intensify the inflammatory reaction and are involved in hypersensitivity (allergic) reaction.
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| Basophils have the same function as the mast cells |
✸ For extra knowledge, mast cells is one of kind of connective tissues that originate from pluripotential stem cells in red bone marrow. Just like basophils, this cells released substances involved in inflammation such as heparin, protease and histamine.
I hope everyone can still stay awake because the cells i am going to indroduce is........
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| MONOCYTES |
As for monocytes, this cell arrived a bit late compared to neutrophils but they will arrived in a large number and destroy more microbes than other WBCs. On their arrival, monocytes will differentiate into wandering macrophage, which clean up cellular debris and microbes by phagocytosis. Their action is just like our mother with their vacuum cleaner to clean up the dust or rubbish on the floor.
Lastly, we have the lymphocytes. Lymphocytes are the major soldiers in lympathic system battles. Most of them continually move among the lymphoid tissues, lymph and blood, spending only few hours at a time in our body. We have three different types of lymphocytes ; B-cell, T-cell and natural killer cells.
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| B-cell & T-cell |
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| THE NATURAL KILLER CELLS...YEAHHH |
B-cells particularly effective in destroying bacteria and inactivating their toxins whereas T-cells attack the infected body cells and tumor cells, and also responsible for the rejection of transplant organs. The immune response carried out by the B-cells and T-cells help combat the infection and provide protection against some disease by producing antibodies. For natural killer cells, they attack wide variety of infected body cells including tumor cells.
FUUHHHH at last we managed to learn how our white blood cells work inside our body. Hopefully everyone managed to gain some knowledge about it and always appreciate and take a good care of our body. It is much better to stay healthy rather than suffer with many illness.
That all from me. UNTIL WE MEET AGAIN IN THE NEXT SESSION😊😊😊😊😊😊😊 BYE BYE 🙋🙋🙋🙋🙋🙋
OOPSS before that to summarize everything that we learned try watch this video hope it beneficial for you😉😉😉
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