HEMOGLOBIN CATABOLISM!!🎃
Salam and hello
pepoool…sleepyhead in da house!!..hehehe a.k.a alya azman, anywaaay are you
guys still following and keep viewing on our blog??? Well peeps you should be!!
Just in case all of you peeps have been following and keep viewing our blog and
have been waiting for the updates patiently with full of anticipation I would
like to thank all of you pepol for spending your precious time to read and
explore our blog!!💝💝💝....
As for the entry
today 😊… I would like to share with you peeps as
sharing is caring and acknowledge every beautiful creature out there including
yooou!! about how on the earth the hemoglobin catabolism occurs in our boddeh 😎😎..
Anyway… before
proceeding with the main topic, just kinda let me give you guys a short brief
regarding what on the earth is hemoglobin catabolism. Well basically, the red
blood cells are unable to divide or to replenish their numbers and the old
ruptured cells must be replaced by totally new cells. Like us human being we were born to this
world to do wonders, we eventually grew up… we explore and experience the
world, when the right time comes we will actually die.. … Did you guys know
that our red blood cell life-time is averagely ONLY 120 days… ISN’T it just
amazing!! Our red blood cell can do wonders in our body for 120 days, *SIGH*
sadly it ONLY survived for 120 days BUT don’t worry no more pepol as there is
this such thing called as erythropoiesis, which will form and replenish the red
blood cells that died. Red blood cells are continuously undergoing a hemolysis
(breaking apart) process... As the red blood cells disintegrate, the hemoglobin
is degraded or broken into globin, the protein part, iron (conserved for latter
usage), and heme. The heme initially breaks apart into bilirubin, a green
pigment which is rapidly reduced to biliverdin, which is an orange-yellow
pigment.
Dear beautiful
creatures,
Like everything
happens for a reason hooneeh, so does all the process that occurs in the
hematology catabolism 😁.Whereby the bilirubin
is then transported to the liver where it reacts with a solubilizing sugar
called glucuronic acid.
DON’T YOU EVER
WONDER HOW ON THE EARTH THE BILIRUBIN IS PRODUCED??
Bilirubin is
produced in the macrophage-monocyte system by the breakdown of hemoglobin to
biliverdin and then bilirubin. Bilirubin is carried in the plasma to the liver,
where it is conjugated to form bilirubin diglucuronide and excreted in the
bile. Bilirubin level thus serves as a measure of liver and bile tract
function. Total bilirubin includes both the conjugated and unconjugated (free)
forms and, if elevated, is usually indicative of liver damage or hemolysis.
Bilirubin
oxidizes slowly when exposed to light, so specimens obtained for bilirubin
levels should be protected from light exposure. Freezing also artificially
alters bilirubin levels in plasma samples. Elevated total bilirubin may be
recognized by a visible yellow coloration of the plasma. A standard
colorimetric assay for total bilirubin involves a diazotization reaction.
WHERE DOES ALL
THIS PROCESS OCCURS IN OUR BODY??
Do you guys
honestly, seriously, literally have any idea on where the heck does all these
amayzeng processes occur?? AHAA!!you get it right once again smarty pants.. it
is in the reticuloendothelial cells of the liver, spleen, and bone marrow. The
bilirubin is then transported to the liver where it reacts with a solubilizing
sugar called glucuronic acid.
This more
soluble form of bilirubin (conjugated) is excreted into the bile.The bile goes
through the gall bladder into the intestines where the bilirubin is changed
into a variety of pigments. The most important ones are stercobilin, which is
excreted in the feces, and urobilinogen, which is reabsorbed back into the
blood.
WHAT HAPPENS
LASTLY??
The blood
transports the urobilinogen back to the liver where it is either re-excreted
into the bile or into the blood for transport to the kidneys. Urobilinogen is
finally excreted as a normal component of the urine.
PLEASE DO WATCH THE VIDEO FOR FURTHER UNDERSTANDING😄😄
HEME DEGRADATION PATHWAY
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